Previous articleIndy may play host to the entire NCAA Men’s Basketball Tournament this springNext articleAAA: Travel expected to be down for Thanksgiving holiday Jon ZimneyJon Zimney is the News and Programming Director for News/Talk 95.3 Michiana’s News Channel and host of the Fries With That podcast. Follow him on Twitter @jzimney. Pinterest Google+ Twitter Facebook IndianaLocalNews Twitter WhatsApp (“Cuffs4” by banspy, Attribution 2.0 Generic) A woman who is employed by the University of Notre Dame is charged with 2nd degree murder in connection with a domestic incident in Washington D.C.Nijinsky Latassia Dix, 37, was arrested after police were called, on Saturday, Nov. 14, to an apartment on the report of gunshots. Inside, they found Terry Hickman, 44, who was pronounced dead at the scene.The investigation led them to Dix, who was arrested the same day, according to 95.3 MNC’s reporting partners at ABC 57.Dix is the program director of TRiO at Notre Dame. TRio is a federal outreach and student services programs designed to ensure equal educational opportunity for all Americans. Facebook WhatsApp Notre Dame employee charged with 2nd degree murder in Washington D.C. Pinterest By Jon Zimney – November 16, 2020 1 473 Google+
In a step that may lead to more-effective HIV treatments, Harvard scientists have found that, in a small number of HIV patients, pre-existing mutations in the virus can cause it to develop resistance to the drugs used to slow the progression of the disease.The finding is important because, although researchers have long known that HIV can develop resistance to some drugs, it wasn’t understood whether the virus relied on pre-existing mutations to develop the resistance, or if it has to wait for those mutations to occur. By shedding new light on how resistance evolves, the study, reported in the online journal PLoS Computational Biology on June 7, opens the door to the development of more-effective treatments.“In order to prevent the evolution of resistance, we need to know where the resistance mutations are coming from. It was exciting to realize data from clinical trials could help us solve this puzzle,” visiting postdoc Pleuni Pennings said. “If we understand how the virus develops resistance, we can think of new ways to prevent it.”In a study of data collected in 26 clinical trials, Pennings found that, in patients receiving treatment with a typical combination of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs, the virus is more likely to develop resistance shortly after the start of treatment, or when treatment is restarted following an interruption of a week or more, but is less likely to develop resistance later on during treatment and when patients do not interrupt treatment.It is that finding that pointed Pennings to the conclusion that pre-existing mutations were behind the virus’s drug resistance. Researchers have shown in past studies that resistance that develops early in treatment is likely the result of pre-existing mutations. Resistance that develops later is tied to mutations in the virus that occur after treatment began.Pennings also analyzed data from trials with pregnant women who were treated with the drug nevirapine to prevent mother-to-child transmission of the virus. Those trials show that the evolution of nevirapine resistance due to pre-existing mutations was reduced if the women were treated with the drug ZDV (often called AZT) prior to receiving nevirapine. Among the possible reasons for the reduction is the fact that ZDV reduces the viral population, thereby reducing the number of pre-existing resistant viral particles in the patient.Those findings, Pennings said, suggest that a similar approach, with some kind of pre-treatment, may be useful for all patients who start or restart NNRTI-based treatment.Although the study holds out hope for the future development of more-effective HIV treatments, Pennings emphasized that data used in the study came from trials that exclusively included patients receiving NNRTI or unboosted protease inhibitor treatments. It is unclear whether the results can be generalized to other treatments and to patients who are not enrolled in clinical trials.“It has long been known that treatment interruptions can lead to drug resistance, but it is also clear that in real life such interruptions cannot always be avoided,” Pennings said. “The good news is that there may be ways to prevent the evolution of resistance even if the patient interrupts treatment. Our results suggest that we need to focus on how patients re-initiate treatment after an interruption. I hope to find collaborators who are interested to test these ideas in clinical trials.“It was great to see that models from evolutionary biology could be used to understand data from HIV studies,” she said. “Once I had the data, it was surprisingly easy to find that resistance evolves due to pre-existing mutations in 6 percent of patients who start NNRTI-based treatment. As for the other 94 percent, they have a risk of approximately 2 to 3 percent per year that resistance evolves. As an evolutionary biologist, I am excited to know these numbers, but the immediate next step is to think about how to reduce these numbers to zero.”
Gloria Salvanelli, a 22-year veteran of the marketing business, has opened her own marketing firm, GCS Marketing in Burlington, Vermont, specializing in public relations, advertising, strategic marketing plans, and special events, and servicing the New England/New York area.Salvanelli spent the bulk of her marketing career with small to medium-sized companies, making GCS Marketing a perfect fit to handle the marketing needs of many of the businesses in this region.As a former Marketing Director for Deck House, Communications Manager for Vermont Castings, and Director of Account Services for Evergreen Direct, Salvanelli has planned, budgeted and bought local, regional, and national advertising in TV, radio, magazines, and newspapers.As Public Relations Manager with Serono Pharmaceuticals in Boston, Dow Chemical in Europe, and both Stratton Mountain and Sugarbush Resort in Vermont, Salvanelli placed articles with national papers such as The Boston Globe, The Wall Street Journal, The Burlington Free Press, Newsday and The New York Times. She has also had four segments with the NBC Today Show, along with segments on CNN, ESPN and CBS, to list a few.GCS Marketing opened its doors August 4 as a full-service marketing firm specializing in these four areas of marketing: public relations, advertising, strategic marketing plans, and special events.Salvanelli has also authored articles in national magazines in both Canada and the United States, nominated and included in Who’s Who in American Women, and worked with sports legends such as Bobby Orr and Mike Eruzione for the U.S.O.C.
Click here to subscribe to the Pharr Out BlogHey y’all,I love brownies; brownies are my favorite dessert. I love hiking; hiking is my favorite activity. Now back to brownies…. Forget crème brulee, layer cakes, and cookies (except if they are Miles’ cookies), I want chocolate fudge brownies without nuts and with extra chocolate chips.Some people like to savor their brownies, and appreciate every bite slowly. I am not one of those people. If someone puts a brownie in front of me, I don’t just eat it; I devour it. With restraint out the window and very little concern for what others think, I scarf down however many brownies are in front of me… and then I lick the plate. Oh, and I like my brownies straight out of the oven… still warm.Now to hiking. No one can doubt that I love to hike. I love to be on a trail by a mountain, a valley, a river, on top of boulders, wherever. I can’t get enough of hiking. Sometimes when I hike I want to indulge in the trail, the miles, and the wilderness. I want to consume it so completely and quickly that at day’s end I feel like I was a hiking glutton. Some folks like to savor every step of their hike, spreading it out to make it last longer. I respect and sometimes even envy those people. Someday, after this hike, I suspect I will be more like them.But for now I have a voracious appetite for hiking. And I like my hiking hot, meaning dead of summer, 95-degree, 90% humidity hot. I complain when I see my breath on a cool mid-July morning in Connecticut, but I never complain about the heat. The heat is my friend.So why all this talk about hot brownies and hiking in warm weather? Well, I’ve realized over the years that some people- both on and off the trail- struggle to understand why I hike the way I do. I certainly don’t feel the need to justify my hiking style to them any more than I feel they need to justify their style to me. But in an effort to help folks understand why I hike this way, I’ve begun to use the brownie comparison. When I hike, I devour miles like I devour hot brownies, not so much because I want to set a record but because I want to get the most out of the experience, and to me this means consuming the trail in great chunks.Ok, enough brownie metaphors. I love it when real people bring real brownies to the trail. Brew and I have kept mostly to ourselves on this hike, but once we reached Connecticut some dear friends from my first thru-hike came to the trail bearing hordes of goodies, including some of the best brownies ever. Along with the crew came my friend J (aka “Jukebox”). He was one of my best friends on my first thru-hike and continues to be a tried and true part of my life several years later. He spent a morning pacing me on the trail and then played guitar and enjoyed a beer with Brwe while waiting for me to finish up.Once I reached New York a very hospitable and accomplished ultra runner named Steve came to make sure I was putting in my miles and working hard. That night, he and his wife Mary Ellen provided us with a shower, an amazing dinner, and a very comfortable bed. We have felt very blessed recently by the trail and the provisions, and I feel very fortunate to be out here chewing up miles… and brownies. 🙂
Chief among these issues is what the congressman calls an attack on Medicare and Social Security, and he said he planned to fight back for more than just the residents of his district. “Being a representative from a congressional district with many older Americans, it’s important for me to be advancing the needs of older adults across this congressional district, and these issues don’t just apply across NY-22,” Brindisi said. “They apply all over the country.” At the Johnson City Senior Center, Brindisi was joined by local leaders to announce the details of this Gray New Deal. Labeling it as a bipartisan effort to help america’s seniors, Brindisi said it was high time to tackle initiatives aimed at helping the elderly. Titled the Gray New Deal, Congressman Brindisi says these bills would focus on improving quality of life for seniors. The representative said this is a five pronged approach: Limiting prescription drug costs, protecting social security, fighting against age discrimination, empowering family care givers and cracking down on robocalls. JOHNSON CITY (WBNG) — Congressman Anthony Brindisi was in Johnson City Monday to announce a new series of federal healthcare related legislation. Brindisi said programs such as Medicare and Social Security are not so called entitlement programs, but earned ones, and said fighting to keep them that way is one of his top priorities.
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The county of Somerset carries two principal arterial routes – the M5 and the A303. Although these roads do not converge, there is a link from the A303 to the M5 at junction 25, which serves Taunton. In addition, Taunton benefits from being on the main London to Exeter rail route: the fastest journey time is one hour 40 minutes.Major property developments are focused on, or close to, these roads and within Taunton. The towns of Bridgwater and Yeovil have also benefited from being close to arterial routes. Frome, the other major town in the north-east of the county, tends to look towards Bath and Bristol for its core business.Retail Somerset has enjoyed increased activity in the past 12 months. Taunton Town Centre, in particular, has seen good results from its enhancement scheme.Marks & Spencer’s recently established presence has affected trading patterns in the town. There has been more activity in the stretch of East Street surrounding Marks & Spencer and opposite, which has led to a dramatic rise in Zone A rents. Nearly 10 years ago, these peaked at just under £100 before falling to £70-£75. The latest letting at 8 East Street shows a Zone A rent of over £100. It will be interesting to see whether this level is supported by further transactions.Taunton is a town which has grown substantially. This factor, along with the tight geography of the town centre, has led to high Zone A levels. It is expected that they will spill over to secondary areas in due course.OfficesThe office market in most Somerset towns tends to be dominated by professionals. With increased business activity, demand for professionals has risen steadily in the past decade and there is no sign of this halting. Several professional firms have outgrown their premises and others are looking to improve their office working environments. So the search is on for better quality buildings. Developers have found it difficult to bring forward schemes to satisfy this demand, which generally does not provide enough single large enquiries to trigger projects. This pressure will continue and it is likely that demand will lead to a development taking place eventually.Industrial and distribution The south-west is not a region which attracts heavy industry. The manufacturing base consists mainly of large numbers of small businesses, and this is set to continue.The location of Taunton, Bridgwater and Wellington has attracted distribution centres such as Argos, with 27,870 sq m (300,000 sq ft) at Bridgwater and Leo, with 16,720 sq m (180,000 sq ft) at Wellington.Recent schemes in Taunton have attracted motor dealers such as Alpha Romeo/Fiat into a new build property and Toyota and Mercedes into existing buildings. There is a new build for Nissan at Chelston and other dealers are seeking sites.The A303 is often overlooked as a commercial artery but at Wincanton, there is a thriving light industrial base. Further land has been allocated for employment development in the draft local plan. There have been a lot of enquiries about this location and it is likely that development will proceed before too long.The south-west will continue to attract light industry and the professional office base will keep growing. The structure plan is seeking to place 50,000 new homes in Somerset before 2011, and prospects for business and retailing look positive.
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Help for Hong Kong has won rare bipartisan support in politically polarized Taiwan and three opposition parties have introduced bills to make it easier for Hong Kongers to live in Taiwan if they have to leave the city due to political reasons.Taiwan has no law on refugees that could be applied to protesters seeking asylum, but its laws promise to help Hong Kongers whose safety and liberty are threatened for political reasons.Some say Tsai’s government is not moving fast enough.”Please come up with details of the humanitarian relief at the soonest. Don’t wait until people shed blood like water,” said Chen Yu-jen, a lawmaker from main opposition Kuomintang party.Ivan Tang, a Hong Kong pro-democracy activist, welcomed Tsai’s support but cautioned a sense of urgency among protesters in the city, some of whom had been barred from entering Taiwan due to travel restrictions amid the coronavirus pandemic.”They have nowhere to go… but the security law could be implemented soon,” he said.Taiwan has become a popular destination for Hong Kongers leaving the city, with the number of Hong Kong citizens granted Taiwan residency jumping 150% to 2,383 in the first four months of 2020 compared with a year ago, official data shows.University applications to Taiwan from Hong Kong also rose 62% in 2020 from a year ago, and island’s education ministry said this week it was planning to raise the quota for Hong Kong students. He said counseling services will also be available for Hong Kongers, some of whom may take part in increasingly violent pro-democracy protests in Hong Kong.”Many Hong Kongers want to come to Taiwan. Our goal is to give them settlement and care,” Chen said, urging the public not use the word “refugee” as it could be “emotionally harmful” for people from the city.Chen, however, did not give details such as scale, timing and qualification of the relief program when pressed by lawmakers, saying the government is still working on the details.Hong Kong’s demonstrators have won widespread sympathy in democratic Taiwan, which China considers as its territory to be taken by force, if necessary. Taiwan has shown no interest in being ruled by autocratic China. Topics : Taiwan on Thursday promised to settle Hong Kongers who flee the Chinese-ruled city due to political reasons, offering help from employment to counseling as China pushes new security legislation that has triggered fresh protests.Taiwan President Tsai Ing-wen this week became the first world leader to pledge specific measures to help people from Hong Kong who may leave the former British colony due to the new legislation, a move that is certain to sour already poor ties between Taipei and Beijing.Chen Ming-tong, head of Taiwan’s top China-policy maker, the Mainland Affairs Council, told parliament the government will establish an organization to deliver “humanitarian relief” that includes settlement and employment in a joint effort with activists groups.
Juventus hope the sale of Paulo Dybala could raise in the region of €100millionJuventus hope to raise in the region of €100million from the sale of Paulo Dybala in a bid to raise funds to finance a move for Benfica sensation Joao Felix.The 19-year-old has been dubbed the most exciting talent in Portuguese football since Cristiano Ronaldo and enhanced his burgeoning reputation in midweek with a hat-trick against Eintracht Frankfurt in a Europa League quarter-final first leg.Juventus have already committed to paying Aaron Ramsey a reported £400,000-a-week having confirmed his transfer from Arsenal in February and handed Cristiano Ronaldo an even more lucrative contract when they signed him from Real Madrid last summer.AdvertisementAdvertisementDybala, meanwhile, has struggled to maintain a regular starting position in Max Allegri’s side and could, according to Tuttosport, be deemed surplus to requirements in the summer, despite having scored 10 goals in 37 appearances this season.ADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityManchester United have been linked with Dybala in the past and are also credited with an interest in Felix, along with Manchester City, Bayern Munich, Real Madrid an Barcelona.Ole Gunnar Solskjaer is expected to oversee a major overhaul of his first team squad this summer and will focus on strengthening at full-back, centre-half and a creative forward capable of playing on the right wing.Speaking about the task he faces in rejuvenating his squad in the summer Solskjaer said: ‘I’m under no illusions that this is not going to be plain sailing, it’s going to be hard.‘It’s going to be survival of the fittest or survival of the best. That’s how ruthless we have to be. We need players here who are going to be able to take us forward. Juventus will sell Paulo Dybala to fund move for Manchester United transfer target Joao Felix Advertisement Joao Felix scored a hat-trick in Benfica’s win over Eintracht Frankfurt in midweek (Picture: Getty)‘That means culture in the dressing room and what we do every single day here to make us challenge again.‘Liverpool and City are too far ahead at the moment for what we like. We played against a Barcelona team that sets the standard in European football.‘We’re under no illusion it’s going to be hard work and there will be some tough decisions made by me, Mike [Phelan] and the club.‘We have a certain standard here. We got a great boost, now it’s more challenging times with the results and performances.’More: Manchester United FCRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseEx-Man Utd coach blasts Ed Woodward for two key transfer errors Comment Metro Sport ReporterSaturday 13 Apr 2019 1:07 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link402Shares Advertisement