We were powerless to resist Real Madrid C.F. firepower, says Massimiliano Allegri

first_imgJuventus manager Massimiliano Allegri said even his side’s rock-like defence was powerless to resist Real Madrid’s firepower as the Italian club’s hopes of a first Champions League triumph in 21 years ended in heartache on Saturday.The Italian champions’ defensive wall had been almost impregnable all season in Europe but was reduced to rubble as Real roared to victory with three goals after the break.”In the first half we played beautifully but they pushed the accelerator in the second half and we could not resist,” Allegri, whose side had been bidding to become the eighth club to land the “treble” having won Serie A and the Copa Italia this year, told reporters.Juventus leaked three goals in 12 games en route to the final, twice shutting out Barcelona’s feared attack in the quarter-finals before blunting a free-scoring Monaco strike force in the semis.But the granite-like trio of Giorgio Chiellini, Andrea Barzagli and Leonardo Bonucci cracked after Juventus had been the better side in a first half that ended 1-1.”The two goals in quick succession hurt us and we were not able to react,” Allegri said.”The only criticism I could make is that after the second goal we should have stayed in the game mentally to make sure we still had chances.”In a sizzling first half, Cristiano Ronaldo put Real ahead before Mario Mandzukic’s incredible overhead kick, one of the great European Cup final goals, deservedly drew Juventus level under the Principality Stadium roof.Juventus retreated after the break, though, and Casemiro’s deflected strike restored Real’s lead on the hour before Ronaldo struck the killer blow three minutes later.advertisementAfter substitute Juan Cuadrado was sent off, Marco Asensio rubbed salt into Juve’s wounds as they fell to their fifth successive defeat in a Champions League final.”I had to take some risks tonight,” Allegri said. “We had to try to score a goal, get ahead, and then defend in the second part of the game. But we were not able to do that.”With a bit more luck we could have finished the first half in the lead and then it would have been a different match.”With keeper Gianluigi Buffon close to 40, Barzagli 36 and Chiellini and Bonucci the wrong side of 30, it is tempting to suggest that Juve’s rearguard will soon need rebuilding.Allegri, however, said the crushing defeat was far from the end of the road for his side.”No I don’t think Juve has reached the end of a cycle at all,” Allegri said.”Buffon will still be goalie next season and Barzagli with be with us for another year. They still have lots to give this club. But we can improve the team.”We all need to rest now but after the holidays we will return with new drive and stimulus.”last_img read more

Melanin from Jurassicera mollusk could lead to new tool for cancer diagnosis

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Eumelanin from the Jurassic-era fossil has a nearly identical pump-probe signature as the eumelanin from its modern counterpart, S. officinalis. The finding that eumelanin survives for millions of years opens the opportunity for pathologists to analyze the eumelanin from decades-old tissue samples of cancer patients in order to better understand the different characteristics of a melanoma that spreads versus a melanoma that does not spread. Credit: Mary Jane Simpson, et al. ©2013 American Chemical Society The researchers, Mary Jane Simpson, et al., led by Professor Warren S. Warren at Duke University in Durham, North Carolina, have published their paper on their analysis of Jurassic-aged eumelanin in a recent issue of The Journal of Physical Chemistry Letters.”Melanoma is a particularly bad cancer if it metastasizes,” Warren told Phys.org. “Unfortunately, the ‘gold standard’ of conventional diagnostic techniques (essentially, excision followed by pathology) does not do a very good job of predicting which diagnosed cancers are likely to spread. So, how do you fix a bad gold standard for a bad disease?”The best answer is retrospective studies—looking at decades-old specimens from patients, where you know the outcome—and trying to find systematic differences. That is impossible with most pathology methods because the tissue degrades. Our results show that it is possible with melanin-based diagnostics, since the melanin easily survives that long.”The researchers explain that human skin has two types of melanin, eumelanin and pheomelanin. The distribution of these two types assists in the diagnosis of melanoma skin cancer. One way to identify the types of melanin and their distribution in a given sample is to use a molecular imaging technique called pump-probe microscopy. Basically, an ultrafast laser pulse is first used to “pump,” or optically excite, the molecules. Then after a short time delay, one or more follow-up pulses are emitted to “probe” the molecules. By measuring how the probe pulses are absorbed or reflected by the molecules, researchers can obtain a pump-probe signature that reveals information on the molecules’ excitation decay process. Since eumelanin and pheomelanin have different pump-probe signatures, this technique enables scientists to distinguish between them. Citation: Melanin from Jurassic-era mollusk could lead to new tool for cancer diagnosis (2013, June 3) retrieved 18 August 2019 from https://phys.org/news/2013-06-melanin-jurassic-era-mollusk-tool-cancer.html Here, the researchers compared the pump-probe signatures of the eumelanin from the ink sack of a Jurassic-era cephalopod (an ancient molluscan marine animal) with that of a modern cephalopod, the common cuttlefish. (Despite its name, cuttlefish are mollusks, not fish.) Although the Jurassic-era cephalopod is 162 million years older than its modern counterpart, the eumelanin pump-probe signatures of the two animals are essentially identical. This finding shows that eumelanin is extremely stable, and could potentially permit researchers to image archived tissue samples from deceased cancer patients and uncover more information than could be obtained through more traditional methods that analyze other, less stable chemicals. Squid ink from Jurassic period identical to modern squid ink, study shows Journal information: Journal of Physical Chemistry Letters The researchers pointed out that they did find some variations in the eumelanin signatures from the two mollusks. However, they could trace these variations to the larger iron content in the ancient eumelanin compared with the modern sample. Eumelanin from the common cuttlefish is normally bound to a variety of transition metals such as iron, copper, and manganese, but washing the eumelanin with the solid acid EDTA removes the majority of the bound metals. When the researchers washed the ancient eumelanin with EDTA, its signature closely matched that of the modern, mostly iron-free eumelanin. Because iron affects the pump-probe signature of eumelanin, the microscopy technique could also potentially enable researchers to approximate the iron content of a sample. For example, pigmented human tissue often exhibits a wide range of pump-probe signatures, and some of the variation may be due to metal ion binding by the melanin. In the future, pathologists may use this knowledge to their advantage when investigating the molecular composition of eumelanin samples. Explore further © 2013 Phys.org. All rights reserved. More information: Mary Jane Simpson, et al. “Pump-Probe Microscopic Imaging of Jurassic-Aged Eumelanin.” The Journal of Physical Chemistry Letters. 2013, 4, 1924-1927. DOI: 10.1021/jz4008036 Common cuttlefish. ©Jarek Tuszynski / Wikimedia Commons / CC-BY-SA-3.0 & GDFL (Phys.org) —In a world where things seem to change overnight, melanin seems to stay essentially the same for more than 160 million years, a new study has found. Melanin is the biological pigment that determines an animal’s color, and is currently not very well understood. In the new study, scientists have found that a type of melanin called eumelanin from a Jurassic-era mollusk produces a signature when optically excited that is nearly identical to that of the optically excited eumelanin from its modern counterpart, Sepia officinalis, or the common cuttlefish. Because melanin survives so long, an analysis of the melanin from old cancerous tissue samples could give researchers a useful tool for predicting the spread of melanoma skin cancer in humans.last_img read more

Trinamool Cong on same page over tea garden workers plight

first_imgKolkata: The ruling Trinamool Congress and the Congress were on the same page at the state Assembly on Monday while claiming that injustice has been done with the workers of the tea gardens in the recent Central Budget.In the mentioned case at the Assembly, state Parliamentary Affairs minister Partha Chatterjee triggered the discussion lambasting the Central government’s decision to pay the wages of the tea garden workers through banks and impose 2 percent cess on their wages. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: Mamata”The tea garden workers have been neglected in the recent Budget. There has been hardly any money allocated for the rejuvenation of the tea gardens. But they have now decided to pay the wages of the workers through banks. They should know that there is hardly any bank in close proximity to the tea gardens,” Chatterjee said. He reiterated that the tea garden workers are paid in cash usually by the end of a week so that they can meet their immediate requirements. “They have also imposed cess on the wages. These steps are nothing but an initiative to push the tea garden workers in dire straits,” Chatterjee said. Also Read – Lightning kills 8, injures 16 in stateHe alleged that the Centre had made tall claims for the development of the tea gardens but the Budget has nothing to augment the livelihood of the workers. Taking the cue from Chatterjee, Leader of the Opposition Abdul Mannan said the problem of the tea garden workers has been persisting for some years and the secular parties have often protested against it. “If you give permission, we can form a team of representatives of the MLAs and protest directly. I feel we need to speak directly with the concerned Union minister,” Mannan said referring to Speaker Biman Banerjee. Banerjee then said that the topic may be discussed. Later in the day, Chatterjee said: “I have requested the Left and BJP even to come together. It is an issue of the state and we should ensure the interest of the state first”.last_img read more

Cellphone Hacking Could it Happen to You

first_img Register Now » If the cellphone hacking scandal that caused the downfall of Britain’s best-selling tabloid, News of the World, made you wonder about your own vulnerability, consider these statistics.Globally, telecommunications-fraud losses, which includes cases of mobile-phone fraud, were estimated to hit $72 billion to $80 billion in 2009, up 34 percent from 2005, according to a 2009 survey of security experts from the Roseland, N.J.,-based Communications Fraud Control Association. Hacking alone accounted for $3.2 billion in losses for the telecom industry, says CFCA.What’s more, the problems have likely only expanded as smartphone use has escalated. In the U.S., smartphone ownership grew 60 percent from 2009 to 2010. And then from 2010 to 2011, the increase was 42 percent, according to Javelin Strategy & Research’s July Second Annual Antivirus, Browser, and Mobile Security Report.The uptick is significant because analysts had long suggested that cellphone insecurity wasn’t a huge threat because each phone and service provider offered different operating systems — making the creation of malware for mobile phones tricky. But as the devises proliferate, the category will become increasingly fruitful for fraudsters, according to Boaz Bechar, a vice president of business development at the Tel Aviv-based security firm, Humbug Telecom Labs, which works with international service providers.To protect yours and your company’s data here are three mobile phone security tips to consider:Lock it up. At the very least, make sure your phone and keypad are password protected, says Bechar. On some phones, you might even enable a so-called lock-out in which the phone locks itself after a set stretch of inactivity. “That way, if someone steals your phone, they can’t access your information,” he says. Then, make sure that you use strong passwords that are long and difficult to ascertain. They should also be completely different than the passwords you use for your banking and online accounts. And absolutely do not program your passwords into your phone.Make sure your voicemail password is also hard to crack, says Bechar. Even if you’re not worried about someone eavesdropping on your phone calls, fraudsters can certainly drain your bank account if you’re not wary. The code should be six to eight digits and don’t even consider using 1,2,3,4,5,6,7,8, he says. You might even call your provider and disconnect your ability to remotely check your messages.Watch that app. Last year, more than one million of China’s cellphone users were infected with a virus that automatically sends text messages. How did they catch that virus? They downloaded an antivirus application that they thought would help protect them against hackers. If you want to download encryption software, do. But just make sure it’s from a reputable seller. Bechar adds that sticking to apps in, say, Apple’s App Store, which certifies its apps, can also be a good idea.Keep it clean. Depending on what kind of phone you have, different applications can be used to help you remove your information remotely. For instance, MyMotoblur can erase your data from Motorola devises. Before you sell or discard a device, make sure you erase it then, too. July 8, 2011 min read Growing a business sometimes requires thinking outside the box. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Opinions expressed by Entrepreneur contributors are their own.last_img read more

Facebook Expands Parental Leave Ahead of the Birth of Mark Zuckerbergs Baby

first_img By now you’ve probably heard that Mark Zuckerberg plans to take two months off following the birth of his baby girl. That may sound like a generous chunk of time, especially for a dad, but that’s half of what the Facebook co-founder and CEO could have carved out, per his company’s parental leave policy.  The world’s most popular social network recently announced the expansion of its four-month “paid baby leave” to full-time employees outside of the U.S., regardless of their gender. The augmented benefit, already available to Facebook’s full-time stateside workers, will chiefly impact new fathers and partners in same-sex relationships, Facebook’s head of human resources Lori Matloff Goler recently said on her Facebook wall. The optional leave can be taken any time throughout the year following a child’s birth or adoption.Related: 10 U.S. Companies With Radically Awesome Parental Leave Policies“In reviewing our parental leave policies, we have decided to make this change because it’s the right thing to do for our people and their families,” Goler said. She casually cited improved “outcomes” for children whose parents take time out to be with them when they’re newborns, just as Zuckerberg, whose wife, Priscilla Chan, 30, is expecting in the coming weeks, also recently noted on his wall.For Zuckerberg’s part, the father-to-be says he’s getting ready to be a parent by stocking up on baby gear, which includes his and his wife’s favorite childhood books and toys. The 31-year-old self-made billionaire called taking paternity leave upon the arrival of his firstborn a “very personal decision.” Clearly, it’s one he can afford to make.Related: Randi Zuckerberg’s Simple Secret for Juggling Career and Kids Facebook joins a long list of big-name global tech firms to significantly beef up their parental leave offerings for full-time employees in recent months, including Netflix. The streaming leader set a new standard last Fall, when it announced unlimited paid time off for new parents during their first year of parenthood.Related: Mark Zuckerberg and His Wife Are Expecting a Baby Girl 3 min read November 30, 2015 Register Now »center_img Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Growing a business sometimes requires thinking outside the box.last_img read more