On July 5th and 6th, Phish will return to Boston, MA’s Fenway Park, the iconic home field of the Boston Red Sox, for a two-night run as part of their 2019 summer tour. The shows will mark Phish’s second and third performances at Fenway after their one-off debut at the ballpark 10 years ago on 5/31/09.Phish at Fenway Preview Video – 2009[Video: Phish]In honor of Phish’s return to Fenway Park in 2019, the Red Sox will celebrate the band with a special “Phish Night” on Monday, June 24th, the week before the two-night run. The Red Sox’s “Phish Night” announcement, which begins with the “Tweezer”-referencing line “won’t you step into the Fenway,” notes that the first 1,500 ticket purchasers for the 6/24 game against the Chicago White Sox will receive a limited-edition pennant designed by Phish to commemorate the special event. Ahead of the game, local Phish tribute act Pardon Me, Doug will play a special set on nearby Jersey Street.You can grab your tickets to Phish Night with the Red Sox here. For Groups of 20 or more or other questions, contact Travis Pollio at 617-226-6790 or [email protected] Phish’s 2009 Fenway performance, the band opened the show with a pre-game-style rendition of “The Star-Spangled Banner” from the pitcher’s mound, clad in Red Sox jerseys. While the band themselves are not included in Fenway’s Phish Night announcement, they do not have a show scheduled for that evening as they make their way from Merriweather Post Pavilion in Columbia, MD to Darling’s Waterfront Pavilion in Bangor, ME—a route that takes them right through Boston on June 24th. Will Phish make an appearance to reprise their National Anthem performance at the Boston Red Sox’s Phish Night? We’ll have to wait and see.See below for a full list of Phish’s upcoming summer tour dates. For more information, head here.Phish 2019 Summer Tour6/11 Chaifetz Arena, St. Louis, MO6/12 Chaifetz Arena, St. Louis, MO6/14 Bonnaroo Music & Arts Festival, Manchester, TN6/16 Bonnaroo Music & Arts Festival, Manchester, TN6/18 Budweiser Stage, Toronto, ON6/19 Blossom Music Center, Cuyahoga Falls, OH6/21 PNC Music Pavilion, Charlotte, NC6/22 Merriweather Post Pavilion, Columbia, MD6/23 Merriweather Post Pavilion, Columbia, MD6/25 Darling’s Waterfront Pavilion, Bangor, ME6/26 Darling’s Waterfront Pavilion, Bangor, ME6/28 BB&T Pavilion, Camden, NJ6/29 BB&T Pavilion, Camden, NJ6/30 BB&T Pavilion, Camden, NJ7/02 Saratoga Performing Arts Center, Saratoga Springs, NY7/03 Saratoga Performing Arts Center, Saratoga Springs, NY7/05 Fenway Park, Boston, MA7/06 Fenway Park, Boston, MA7/09 Mohegan Sun Arena, Uncasville, CT7/10 Mohegan Sun Arena, Uncasville, CT7/12 Alpine Valley Music Theatre, East Troy, WI7/13 Alpine Valley Music Theatre, East Troy, WI7/14 Alpine Valley Music Theatre, East Troy, WI8/30 Dick’s Sporting Goods Park, Commerce City, CO8/31 Dick’s Sporting Goods Park, Commerce City, CO9/01 Dick’s Sporting Goods Park, Commerce City, COView Phish Summer Tour Dates[H/T Relix]
In a step that may lead to more-effective HIV treatments, Harvard scientists have found that, in a small number of HIV patients, pre-existing mutations in the virus can cause it to develop resistance to the drugs used to slow the progression of the disease.The finding is important because, although researchers have long known that HIV can develop resistance to some drugs, it wasn’t understood whether the virus relied on pre-existing mutations to develop the resistance, or if it has to wait for those mutations to occur. By shedding new light on how resistance evolves, the study, reported in the online journal PLoS Computational Biology on June 7, opens the door to the development of more-effective treatments.“In order to prevent the evolution of resistance, we need to know where the resistance mutations are coming from. It was exciting to realize data from clinical trials could help us solve this puzzle,” visiting postdoc Pleuni Pennings said. “If we understand how the virus develops resistance, we can think of new ways to prevent it.”In a study of data collected in 26 clinical trials, Pennings found that, in patients receiving treatment with a typical combination of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs, the virus is more likely to develop resistance shortly after the start of treatment, or when treatment is restarted following an interruption of a week or more, but is less likely to develop resistance later on during treatment and when patients do not interrupt treatment.It is that finding that pointed Pennings to the conclusion that pre-existing mutations were behind the virus’s drug resistance. Researchers have shown in past studies that resistance that develops early in treatment is likely the result of pre-existing mutations. Resistance that develops later is tied to mutations in the virus that occur after treatment began.Pennings also analyzed data from trials with pregnant women who were treated with the drug nevirapine to prevent mother-to-child transmission of the virus. Those trials show that the evolution of nevirapine resistance due to pre-existing mutations was reduced if the women were treated with the drug ZDV (often called AZT) prior to receiving nevirapine. Among the possible reasons for the reduction is the fact that ZDV reduces the viral population, thereby reducing the number of pre-existing resistant viral particles in the patient.Those findings, Pennings said, suggest that a similar approach, with some kind of pre-treatment, may be useful for all patients who start or restart NNRTI-based treatment.Although the study holds out hope for the future development of more-effective HIV treatments, Pennings emphasized that data used in the study came from trials that exclusively included patients receiving NNRTI or unboosted protease inhibitor treatments. It is unclear whether the results can be generalized to other treatments and to patients who are not enrolled in clinical trials.“It has long been known that treatment interruptions can lead to drug resistance, but it is also clear that in real life such interruptions cannot always be avoided,” Pennings said. “The good news is that there may be ways to prevent the evolution of resistance even if the patient interrupts treatment. Our results suggest that we need to focus on how patients re-initiate treatment after an interruption. I hope to find collaborators who are interested to test these ideas in clinical trials.“It was great to see that models from evolutionary biology could be used to understand data from HIV studies,” she said. “Once I had the data, it was surprisingly easy to find that resistance evolves due to pre-existing mutations in 6 percent of patients who start NNRTI-based treatment. As for the other 94 percent, they have a risk of approximately 2 to 3 percent per year that resistance evolves. As an evolutionary biologist, I am excited to know these numbers, but the immediate next step is to think about how to reduce these numbers to zero.”
With the global economy seeing early signs of recovery, businesses are now looking at IT to create value and become more agile to create differentiation in a highly competitive marketplace.For IT organizations, this creates a real challenge. We are dealing with the perpetual necessity to cut costs whilst balancing the need to invest in emerging technologies and innovative ways to augment the IT value chain. It seems, however, there is a simple answer: ‘Software-Defined’ with ‘No Limits’!With VMworld Europe concluding today, you can expect a catalyst of momentum around how software is empowering IT to break down walls, demolish barriers and reveal the opportunities ahead.To celebrate and examine this concept in more detail, the Financial Times asked EMC and VMware to record a short video series on the key elements of how to drive business value through IT Transformation. Over the next few weeks we will release a total of five videos, each addressing an area to cover when considering a transformation. To follow the series, bookmark this blog!Chapter One – Drivers for IT Transformation In the first of this series of master-class videos, we explore how the convergence of cloud, big data and mobile technology is driving IT transformation across businesses.With traditional business models being disrupted by these new technologies, senior technologists from EMC and VMware discuss why, despite pressures from the business for IT organizations to cut operational costs and address the burden of legacy IT applications and infrastructure, changing business expectations in a recovering economy are creating a phenomenal opportunity for organizations to create first mover advantage – if IT can keep pace with the business.Coming soon:Chapter 2: Transforming Your Infrastructure and Delivering a Well Run Hybrid CloudChapter 3: Transforming the Operating Model and enabling the Software Defined EnterpriseChapter 4: Transforming Applications and preparing for the Third PlatformChapter 5: Partnering to Enable Successful Transformations
DIRECTOR of Sport Christopher Jones made good on a promise of backpacks to the male and female winners of the recently concluded Allister Munroe-organised Al Sport and Tour Promotions/National Sports Commission 22nd Annual End of School Year Primary Schools Edward Cobenna Memorial Windball Cricket Champions Trophy. At a simple meeting at the National Sports Commission Boardroom yesterday, Jones presented the backpacks to the 2019 winners Ketley Primary School (females) and the Winfer Gardens Primary School (males).In the female final last month, Ketley Primary won their first major windball title after they defeated Sophia Primary in the grand finale. In that game, Sophia lost the toss and were sent in to bat. The eventual second place finishers stroked 63-2 from their allotted overs with Kiazianna Thompson leading the attack with 20.In reply, Tia Fowler had smashed four sixes in a top score of 36. Fowler, who was later named the Player-of-the-Tournament had also picked up a wicket.Winfer Gardens also won their first Edward Cobenna Memorial Windball title last month.The East Street School defeated West Ruimveldt Primary in their final. West Ruimveldt batted first and scored 81-2. Jonathan Andries (32) and Vikash Asram (22) led the attack for the eventual second-place finishers.Winfer Gardens, in reply, reached 82-4 in the final over to win the title. Shane Prince had struck 38 to lead the charge.
JEFF SCHORFHEIDE/Herald file photoA season-high 740 fans attended the season finale, butWisconsin’s softball team was unable to feed off the vocal crowd. After pitcherLeah Vanevenhoven gave up five runs in the second inning, UW appeared to beemotionally deflated and was never able to muster a rally.This was in stark contrast to the day before, when theBadgers made several impressive defensive plays and kept Minnesota off thescoreboard until the eleventh frame.“I think on Saturday we just went out there, had fun andplayed with our hearts,” sophomore pitcher Letty Olivarez said of herteammates. “It was our final day, it was senior day, and we wanted to play forJoey [Daniels] and Lynn [Anderson]. It just didn’t carry on over to today. Wecame out quiet and we came out flat, and nobody was there.”Wisconsin’s softball team shut out border rival Minnesotathrough the first ten innings of an eleven-inning game Saturday before freshmanKristyn Hansen gave up four runs in the eleventh. Sunday, the Gophers scored 14runs in the first four innings before the game ended via the “mercy rule” afterthe fifth inning.Inconsistent pitching has plagued the Badgers all year long,and it was fitting that UW would end their season on a note like this.“I think this series clearly sums up our season,” sophomoreLetty Olivarez said. “Our whole season has been like this; one day we are great,the next we are awful. I just hope we learn from it for next year. We have tocommit. We need to commit to every game and every pitch.”Vanevenhoven gave up 11 hits and three walks as she wastorched for nine earned runs in three innings of work. As has been the case allseason, Vanevenhoven received little help from her defense, who committed fourerrors and botched several other plays. Vanevenhoven leads the conference inlosses with 24 on the season, although part of that can be attributed to theleague-leading 69 unearned runs that UW has given up.Wisconsin ran into some bad luck when both of their top pitcherswere injured during Saturday’s game. Vanevenhoven was hit in the hand by a linedrive, which forced her out of the game for one-third of an inning. In theeleventh inning, a line drive hit Olivarez in the knee, forcing her to leavethe game. Olivarez was not available for Sunday’s game, and though Vanevenhovenstarted, she appeared to still be suffering the effects of Saturday’s injury.“Clearly the injuries affected us a bit,” Olivarez said.“Leah wasn’t herself today, and I felt extremely bad that I was hurt andcouldn’t help the team out. Leah was out there battling, but clearly she wasstruggling, and it hurt the team that I was unavailable to pitch.”