It’s been 7 years since dozens of children with progeria—a devastating disease that causes symptoms resembling premature aging—first began receiving an experimental drug called lonafarnib. That’s an eternity for them and their parents given that most afflicted with the extremely rare condition die by their teenage years. There’s now a hint that this medical gamble has paid off, at least to a small extent. The Progeria Research Foundation (PRF), which funded the initial trial of the drug and an ongoing follow-up involving it and two other drugs, announced this week that the interventions have likely added, on average, about 19 months to the children’s lifespans. This is “an important first step,” says Leslie Gordon, a physician who, along with her husband, founded PRF after their son was diagnosed with progeria. “Though these medications are not curative, we show for the first time that lifespan may be influenced in children with progeria.” But that conclusion, detailed in a study published online on 2 May in Circulation, has many scientists questioning whether the results are meaningful, because the trials lacked an untreated control group—as is sometimes the case for extremely rare disease treatments.Only about one in 4 million to 8 million newborns have the mutation in a gene called LMNA that causes what is formally known as Hutchinson-Gilford progeria syndrome. LMNA normally produces a protein that helps provide a scaffold for a cell’s nucleus. The mutation leads to the buildup of an abnormal version of the protein, which causes misshapen nuclei and other changes within cells. The ultimate result is a collection of symptoms that resembles premature aging of certain tissues: hair and weight loss, thin skin, joint stiffness, and atherosclerosis. The latter leads to heart attacks that cause the majority of deaths from the disease.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In 2005, a study led by researchers at the University of California, Los Angeles, showed that a class of drugs called farnesyltransferase inhibitors (FTIs), which block the attachment of a molecule to the faulty protein that allows it to accumulate around the nucleus, restored normal shape to cells from kids with progeria. Several groups working with mice having the same mutation next established that the drug also reduced signs of premature aging in those rodents. Because FTIs had already been tested in children with cancer, with no significant side effects, PRF quickly pushed to start a trial of the FTI lonafarnib in 2007. Gordon, working with a team led by oncologist Mark Kieran of the Dana-Farber Cancer Institute in Boston, initially followed 25 children as they received the drug for at least 2 years. The trial results, published in 2012, showed that many of the patients had small weight gains and reductions in the stiffness of their blood vessels, though some scientists found the results inconclusive and hard to interpret.In the new analysis, Gordon and her colleagues wanted to see whether children treated so far—including those in the first lonafarnib trial and those in an ongoing trial that adds two other drugs to the treatment—survived longer than untreated kids. But because there are so few children with progeria, and the disease is invariably fatal, PRF and the study designers had agreed not to create a group receiving a placebo; all who participated in the study received the drug, including Gordon’s son. For a comparison group, Gordon and her colleagues instead collected data about untreated children from historical records in the foundation’s international registry, previously published case reports, and public databases.That’s what makes some question whether the apparent lifespan extension is real. Studies with historical controls are “notoriously unreliable,” says Donald Berry, a biostatistician at the University of Texas MD Anderson Cancer Center in Houston. Because various studies and databases may have different criteria for including a patient, factors outside the efficacy of the drug could contribute to differences in lifespan. Gordon and her colleagues, however, tried to address this issue by matching children in the treatment group with untreated kids of the same age and gender, born on or after the treated subjects. The comparison found that in the 6 years after starting treatment, those receiving the drug survived, on average, 1.6 years longer than their untreated counterparts. Over that period, 21 of 43 children with progeria who hadn’t enrolled in the study died, compared with 5 of the 43 who had received a treatment.The finding “is very gratifying and encouraging,” says physician-geneticist Francis Collins, who is director of the National Institutes of Health in Bethesda, Maryland, and whose research team has studied the mechanisms of and potential treatments for progeria. Collins acknowledges that the lack of a direct control group enrolled in the trial is “not ideal,” but he notes “there really wasn’t much of an alternative to what was done—namely, to do an open-label trial where all of the kids were given the chance to have access to the drug.”But others, including Berry, have trouble drawing a positive conclusion from the study in light of that limitation. He notes that a more dramatic improvement in lifespan might have overcome his doubts: “Had the patients lived a normal life span then the results would have been compelling. But even an improvement of ‘only’ 10 years (and possibly even 5 years) would have been enough to establish the principle that the treatment was effective.”Beyond the age and gender issues Gordon’s team addressed, there are untold differences between trial participants and the untreated group, notes Howard Worman, a cell biologist and physician at Columbia University, who was the first to characterize the LMNA gene. The children and their parents who enroll in a clinical trial may be more aware of their disease and more proactive with their health than nonparticipants, for example. “Until there’s a matched, concurrent, ideally placebo-controlled group, it’s hard to say if there really is a survival advantage,” he says.Gordon and her colleagues continue to track the children in the study, who are still taking the FTI and the two other medications—more time may make any survival advantage more obvious. Her son, recently the subject of an award-winning documentary, died in January.
China raised the curtain today on the most ambitious act yet of its lunar exploration program. At just about 2 p.m. Eastern Daylight Time, the Chang’e-5 Test 1 (CE5-T1) spacecraft lifted off aboard a Long March rocket for an unmanned dash to the moon and back that aims to test technology for a sample return mission planned for 2017 and, a decade from now, possibly landing astronauts on the moon.CE5-T1 marks China’s fourth lunar mission in the Chang’e series, named after a moon goddess in Chinese mythology. Chang’e-1, launched in 2007, spent 16 months in orbit snapping the nation’s first images of the lunar surface. Previous Chang’e probes were left in space. Guiding CE5-T1 back to Earth poses a new challenge; entering the atmosphere at a speed of 11.2 km/s is nearly 50% faster than the return speed of China’s Shenzhou spacecraft, which has carried orbiting astronauts safely back to Earth’s surface.“Earthbound experiments can’t effectively simulate the complexity of the atmospheric environment,” Hao Xifan, deputy chief designer of the CE5-T1 and Chang’e-5 missions, told China’s S&T Daily newspaper shortly before the launch. He says CE5-T1 may be the sole spacecraft launched for engineering testing during China’s unmanned lunar exploration program.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)According to Hao, a skip-reentry technology will be used to slow down CE5-T1. Comparing the technology to skipping a stone on a lake, he explained that the spacecraft will first dip into the atmosphere, then jump up, and finally make a gliding reentry toward touchdown. “The jump must be well controlled. If it’s too low, the probe may be burnt. If too high, it won’t be able to land in the targeted area.”CE5-T1 is expected to arrive in lunar orbit on 26 October. It will orbit the dark side of the moon and then head home, with a parachute-assisted landing somewhere in middle Inner Mongolia 8 days after its departure.“Although the upcoming mission is very risky, I have full confidence [in our success],” Liu Jizhong, deputy commander of China’s lunar exploration program, told S&T Daily.Joining CE5-T1 atop the Long March 3C rocket today are two small probes from Europe. One is a radio beacon known as 4M. Developed by LuxSpace in Luxembourg, 4M will start transmitting radio signals back to Earth for amateur space enthusiasts soon after the liftoff. The other microsatellite is PS86X1 from the virtual organization Pocket Spacecraft. They will bid farewell to CE5-T1 on the way to the moon and conduct separate lunar flyby experiments.CE5-T1 is a steppingstone to Chang’e-5, China’s last planned uncrewed mission to the moon. Among many other tasks, Chang’e-5 is slated to collect about 2 kilograms of lunar soil and return to Earth.
India’s tourism ministry is planning to set up offices in the United States, United Kingdom and Russia to boost the arrival of visitors to the country. The government will also establish facilitation centres at airports in metropolitan cities such as New Delhi, Mumbai and Bengaluru to assist tourists when they land in India.The Indian government, which had earlier this year announced the launch of its Incredible India 2.0 campaign to showcase the country as a prime tourist destination, is mulling several steps to spur growth in the sector. Among the projects in the pipeline are market-specific campaigns in various countries across different media platforms.“We feel a synergy between the Incredible India campaign and different overseas markets will get us better results,” tourism secretary Rashmi Verma told the Economic Times. “Our offices in different countries would work on a hub and spoke model which will be in sync with our public relations agency. This time the state governments are also complementing our plans and the industry can plan marketing campaigns around it. Our spends are higher than last year.”The new campaignThe new Incredible India 2.0 campaign, scheduled to be launched on September 27, which is marked as World Tourism Day, will also involve a revamped interactive website. “We are also looking at crowd-sourcing content… blogs and comments, including on social networking sites, about a particular place will be also put up on the site,” Verma had earlier told The Hindu.Foreign tourist arrivals to India showed a 15 per cent growth from January to July this year, with around 56.74 lakh tourist arrivals in the period, as compared to a corresponding figure of 49.03 lakh in the same period last year, according to tourism ministry data released by the ministry in August. While most number of tourists (20.12%) arrived from Bangladesh, the US came next with 16.26%, followed by the UK (10.88%) and France (3.01%), the data showed.An increase in foreign exchange earnings through tourism was also recorded in the period from January to July this year, with Rs 1,02,082 crore collected as compared to Rs 87, 034 crore in the same period last year.The Incredible India 2.0 campaign will focus on, among the other things, the rich cultural heritage of India. The country’s ancient spirituality and wellness traditions are expected to get a fillip, as the government plans to develop at least 10 cities with potential in spirituality and wellness sectors that can be promoted. Among the places being considered for development in this regard are Guwahati, Kanyakumari, and Lahaul and Spiti, besides Ayodhya and Mathura.Cruise tourism Also taking shape are the government’s plans in the cruise tourism sector. A task force set up by the government in November 2015, co-chaired by Shipping secretary Rajive Kumar, and tourism secretary Rashmi Verma, have for a year worked with consultant firm Bermello and Ajamil (B&A) to prepare a roadmap for cruise tourism in the country. With many issues such as e-visas and landing cards for tourists and cruise ship crew members, cabotage, and rules related to leisure boats and costal regulatory zone being addressed, it is hoped that the project may be ready for launch by the end of this year.Indian has an enormous potential for cruise tourism, and the sector, according to B&A, can create 250,000 jobs and generate revenues of over Rs 35,000 crore for the government, according to Moneycontrol.com.India is obviously sitting on a huge untapped tourism potential. The total market size of Indian tourism and hospitality sector, which was $117.7 billion in 2014, is expected to reach $418.9 billion by 2022, according to industry estimates.“A goldmine of an opportunity awaits to be tapped,” the first ever mid-year Economic Survey released in August said.The survey showed that India’s share in international tourist arrivals in 2015 was mere 1.1 per cent while the top-ranking country, France, recorded a corresponding figure of 7.1 per cent and China was placed fourth with a share of 4.8 per cent. Also, although India’s ranking has gone up 12 spots to reach the 40th position among 136 countries in the ‘Travel and Tourism Competitiveness Index 2017’, it is still far behind the other nations in parameters like health and hygiene, security, human resources and tourist infrastructure. Related ItemsIncredible India 2.0 campaignIndia cruise tourismIndia foreign exchange tourismIndia foreign tourist arrivalsIndia spiritual tourismIndia tourismIndia wellness tourismLittle India
Former world champions Italy and Spain played to 1-1 on Thursday, giving a chance for unheralded Albania to take the lead in their Europe qualifying group.Elsewhere, Mario Mandzukic bagged a hat-trick as Croatia beat Kosovo 6-0, while Wales conceded the lead twice away in Austria in a draw.GROUP GSpain lost to Italy in the round of 16 at the European Championship, and was set for a measure of revenge in Turin.Spain’s Vitolo scored in the 55th minute following a rare mistake from veteran Italy goalkeeper Gianluigi Buffon.But Daniele De Rossi converted a penalty with eight minutes remaining after Eder was tripped by Sergio Ramos, and preserved his team’s formidable home record. Italy has won 43 World Cup qualifiers, drawing the other seven.Spain and Italy are level on points in Group G after winning their opening qualifiers. Only the top team qualifies for the 2018 World Cup in Russia automatically.Albania moved to the top after winning in Lichtenstein 2-0 to maintain its perfect start to its qualifying campaign.Goalkeeper Peter Jehle turned into his own net, and Bekim Balaj, who also netted the winner against Macedonia, scored in the 71st.Israel moved into fourth with a 2-1 victory in Macedonia.Italy visits Macedonia on Sunday, when Spain travels to Albania.GROUP IMandzukic proved unstoppable, ruthlessly exploiting Kosovo’s inexperience and scoring his three in the first 35 minutes. However, celebrating Croat fans spoiled their team’s show by chanting in Serbo-Croatian, “Kill, kill the Serbs” in the second half, and they were echoed and followed by Kosovo fans, too, in Albanian.advertisementKosovo became a UEFA member in May, joined FIFA a week later, and was fast-tracked into World Cup qualifying though many nations still have not recognized it.After Kosovo earned a credible draw at Finland last month, this was its first competitive home game but played in Albania’s northern city of Shkodra, as Kosovo has no stadium certified by UEFA.Croatia was without star midfielders Ivan Rakitic and Luka Modric but had another star available: Mandzukic needed just six minutes to open the scoring off a pass from Andrej Kramaric.Mandzukic met Ivan Perisic’s cross to head home and double the lead, and completed his hat trick with another header 10 minutes before the interval, this time using a cross from Sime Vrsaljko, for his 27th goal in 71 internationals.With the damage done and the result beyond doubt early, Mandzukic was substituted by Nikola Kalinic in the 58th.”It’s better it occurred today, and I am convinced we shall represent ourselves better at the next match,” Kosovo midfielder Bernart Berisha said. “There was no good communication between the defense and the midfielders.”Iceland rallied in the final minutes to earn its first victory in qualifying, 3-2 over Finland.Alfred Finnbogason leveled the score in the final minute of the match, and Ragnar Sigurdsson scored the winner deep into stoppage time for the surprise Euro 2016 quarterfinalist.Hakan Calhanoglu converted from the spot nine minutes from time to salvage a 2-2 draw against Ukraine.Croatia is tied atop Group I with Iceland, on four points. Ukraine and Turkey have two points after their 2-2 draw. Kosovo is at the bottom with one.GROUP DMarko Arnautovic twice came to Austria’s rescue to draw 2-2 with Wales in the group where Wales, Serbia, Austria, and Ireland are separated only on goal difference at the top.Knowing the Euro 2016 semifinalists underperformed, it was a frustrating night for Gareth Bale.”We know we weren’t at our best tonight – it was a difficult game,” Bale told British broadcaster Sky Sports. “But this is what we’ve grown up to do. We grind out results when we need them.”When we don’t play well, we defend solidly as a team, and we get something from the game. We are a little bit frustrated.”Wales took the lead with a slick goal in the 22nd minute, with Joe Allen volleying into the net. It was canceled out inside six minutes by Stoke teammate Arnautovic’s downward header.Austria conceded again in clumsy circumstances just before halftime. Sam Vokes flicked on Bale’s long throw-in, James Chester prodded goalward, and goalkeeper Robert Almer saved. But the rebound hit Kevin Wimmer, who inadvertently diverted the ball into his own net.Three minutes in the second half, though, Arnautovic equalized again after seizing on Allen’s misdirected pass and darting through a huge hole in the Wales defense.
Danny Welbeck’s double guided a heavily rotated Arsenal to a hard-earned 3-1 win over Brentford and into the fourth round of the EFL Cup.One of nine changes from the weekend win over Everton, Welbeck was on target twice before a splendid Alan Judge free-kick set up a tense final half hour at Emirates Stadium.The Championship side were emboldened and, for a period, pressed hard in search of an equaliser that ultimately never came, Arsenal stabilising adequately and eventually sealing Unai Emery’s sixth straight victory through substitute Alexandre Lacazette in stoppage time. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! The new Gunners boss is attempting to do something his predecessor Arsene Wenger never achieved in winning this competition, and the quality of several passages in between the stern second-half examination will have delivered belief that is very much a possibility.@DannyWelbeck@LacazetteAlexBring on the next round of the @Carabao_Cup#CarabaoCup pic.twitter.com/Njwavt62sn— Arsenal FC (@Arsenal) September 26, 2018The course of the match might have differed had Bernd Leno’s puzzlingly poor touch from a Shkodran Mustafi back-pass not trickled wide of his own net in the second minute.Instead, Arsenal were ahead moments later as Welbeck rose unchallenged to emphatically head in Matteo Guendouzi’s corner in the fifth minute.His second, eight minutes before the interval, capped a sweeping move with Henrikh Mkhitaryan, Alex Iwobi and the overlapping Nacho Monreal combining to provide a tap-in.An unexpected twist came when midfielder Judge fizzed a brilliant free-kick in off the upright and Brentford almost had an equaliser in quick time, Sergi Canos flashing a shot over the bar.Penalties remained a possibility right until Lacazette put the seal on Arsenal’s victory with a determined finish three minutes into added time, fellow substitute Lucas Torreira with the assist. What it means: Gunners in syncThis kind of banana skin fixture could well have eroded some of Arsenal’s momentum, but Emery’s second string handled the occasion professionally when required and, at times, with real style.Emery’s decision to retain only Monreal and Mustafi on his starting XI was justified as the fluidity of the second goal demonstrated an entire squad operating on the same wavelength.Leno looks the partThough beaten by Judge’s free-kick – for which he could do very little – two moments in the first half served to illustrate how comfortably Leno can slot in should Petr Cech’s form tail off.The German recovered from a nervy early moment to instigate Welbeck’s second with a brave pass from the back, having not long earlier raced off his line to snuff out a counter-attack in true sweeper-keeper fashion.Guendouzi lapse punishedSupplier of the opening goal, Guendouzi undid that good work by offering Brentford a way back into the match after half-time. It was the teenager’s unnecessary foul on the edge of the area which Judge emphatically converted.3 – Danny Welbeck is the first @premierleague player to score in three different club competitions this season (League, Europa League and #CarabaoCup). Spread. #ARSBRE— OptaJoe (@OptaJoe) September 26, 2018What’s next?Arsenal will seek to maintain their winning run when Watford visit in the Premier League on Saturday, the same day as Brentford host Reading in the second tier. read more
Karachi, Nov 17 (PTI) Former Pakistan head coach, Waqar Younis believes cricket boards need to increase their monitoring of franchise based T20 leagues and educate the players to keep the sport clean of corruption.Islamabad United and the Pakistan Cricket Board faced embarrassment last February when two of the national team batsmen, Sharjeel Khan and Khalid Latif were found guilty of meeting with a bookmaker and agreeing to spot fix in the second Pakistan Super League.Both of them, who were with Islamabad United, were suspended and sent back home on the second day of the league from Dubai and have since then been banned for five years by a three member anti-corruption tribunal of the Pakistan board.Sharjeel has had his appeal been rejected by an independent adjudictor but his lawyer, Shaighan Ejaz confirmed that they would be going to the Lahore High Court to file another appeal against the ban as his client was innocent.”The menace of spot-fixing and gambling is like cancer for all sports including cricket and it is very important cricket boards take all steps to root out this problem from all cricket,” said Waqar, who is bowling coach and Director cricket in the Islamabad United franchise for the third edition of PSL.He noted that due to popularity of T20 franchise based leagues, players would be targeted by corrupt elements and they had to be educated to remain on guard all the time.”We are now carrying out a strict monitoring of all players in our franchise and we are confident that there will be no repeat of the last PSL incident this time,” the former captain added.advertisementPakistan cricket has been hit hard by fixing scandals starting with a judicial match fixing inquiry in the 90s which led to life ban on former test captain, Salim Malik in 2000.In 2010, then Pakistan captain Salman Butt, Muhammad Asif and Muhammad Aamir were all caught for spot-fixing during a test at Lords against England and subsequently banned for minimum of five years by the ICC. In 2012, the England and Wales cricket board banned Pakistan test leg-spinner, Danish Kaneria for life after finding him guilty of enticing other players to spot fix and meeting a bookie during the English county championship while playing as a pro for Essex.Some other leading Pakistani players have also come under suspicion over fixing allegations.Waqar also made it clear that more stringent anti- corruption measures should be taken by all boards if necessary and no player should be spared if found guilty of corruption.The former pacer, however, said that while T20 had grown in popularity but the importance of Test cricket remained even now.”Even now everyone knows that no player becomes a big player until he has played and performed in Test matches which is a real challenge.” PTI Cor ATK ATK
Los Angeles, Sep 16 (AFP) Male tennis players are almost three times more likely to be fined for losing their temper and smashing racquets than their female counterparts, The New York Times reported. Male players were slapped with 1,517 fines compared to 535 fines for females according to data compiled by officials at Grand Slam tournaments for the period covering 1998 to 2018. The figures obtained by the Times show that men received 649 fines for breaking racquets to 99 for women in tens of thousands of matches in the four Grand Slams over the last two decades. Men were fined 344 times compared to 140 for “audible obscenity” and 287 to 67 for unsportsmanlike conduct. Last week, Serena Williams accused the chair umpire Carlos Ramos of being a “liar” and a “thief” after she was cited for verbal abuse during the US Open women’s final against Japan’s Naomi Osaka. “Because I’m a woman you are going to take this away from me?” she said to the tournament referee Brian Earley. “That is not right.” In the post-match news conference, Williams doubled down on her claim there is a double standard when it comes to punishment. “I have seen other men call other umpires several things. I am here fighting for women’s right and women’s equality …. and for me to say ‘thief’ and for him to take a game it made me feel like it was sexist,” she said. “He’s never took a game from a man because they said thief. For me, it blows my mind.” She also smashed her racquet and threatened to make sure that the Portuguese umpire never worked another match of hers again in the second set of a 6-2, 6-4 loss to Osaka.advertisement “You will never, ever, ever be on another court of mine as long as you live,” she said during the on court outburst. “You are the liar. When are you going to give me my apology?” The incident led to scores of Williams’ supporters coming to her defence but also to widespread criticism, especially on social media, of the 23-time Grand Slam winner. Williams’ first code violation in the Osaka match was for coaching which women have received 152 fines compared to 87 for men during the 20 years.One factor in the disparity in the data is that men play best-of-five set matches in Grand Slam events while women play best-of-three. – 2009 meltdown – ================= This was not the first time Williams has had a meltdown at the US Open. In 2009, Williams refused to apologize after threatening to shove a ball down a lineswoman’s throat in an expletive-laden outburst. Earlier this year at the Indian Wells tournament, Williams berated a female reporter in the players’ lounge area for asking a question at a news conference about therapeutic use exemptions. One Australian commentator took issue with Williams’s claim she is fighting for women’s rights. “She is doing a terrible disservice to women’s rights, to the #metoo movement, to gender equality,” Caroline Wilson of the Australian Broadcasting Corp. said. “To say she’s fighting for women’s rights, when what she is, is a bad sport.” (AFP) AH
England wicketkeeper-batsman Jos Buttler was scared after his powerful pull shot hit Sri Lankan player Pathum Nissanka on the helmet on the second day of the warm-up match against Sri Lankan Board President’s XI on Wednesday.Nissanka was struck at the top of his helmet while he was fielding at short leg. For around 15 minutes of the match, medics from both teams were treating Nissanka on the ground.However, he was then placed on a stretcher while a neck brace was also put in place as he was carried off the ground.Buttler expressed that he “feared the worst” when his shot hit Nissanka on the helmet and he was worried straightaway.”You always fear the worst, I think. I hit it pretty hard and hit him flush so it was a big worry straight away,” Buttler told reporters at the Nondescripts Cricket Club ground.The incident for many revived memories of the on-field injury suffered by Australian batsman Phillip Hughes in 2014 which proved fatal, but Sri Lanka Cricket (SLC) confirmed Nissanka was out of danger after an MRI scan.Pathum Nissanka, who was playing for the Board XI in the 1st practice game vs England, was hospitalized this evening, after he was hit on the helmet, while fielding at the Short Leg. MRI scan showed that the player is out of danger. https://t.co/CW0myHCiuj pic.twitter.com/GaHfvw9BQsSri Lanka Cricket (@OfficialSLC) October 31, 2018However, the 20-year-old would remain in hospital for 24 hours on observation, SLC added.advertisement”When he went down you are hoping for the best. The doctors and physios ran out and gave great care straight away. You don’t mean to cause injury but it’s a real unfortunate accident,” Buttler added.Earlier on Wednesday, even Ben Stokes got hurt and retired hurt, only to return to bat after the tea break.Stokes was struck near the left elbow as he attempted a pull shot. Stokes continued batting for some time but decided to retire hurt eventually. England had said that Stokes’s elbow was just bruised and he was expected to return to bat, which he did.The two-day practice match between England and Sri Lankan Board President’s XI ended in a draw after 365/7 in 90 overs, following Sri Lankan innings where they declared after scoring 392/9.England next head to Galle, which will host the first match of the three-Test series between the tourists and Sri Lanka from November 6.(With Reuters inputs)
A SIOUX CITY WOMAN WHO WAS IN THE CROWD DURING THE LAS VEGAS MASS SHOOTING SAYS, “AMONGST THE CHAOS, THERE WERE THE “HELPERS”.KATIE BURGETT WAS IN THE MIDDLE OF THE AUDIENCE AS A GUNMAN STARTING SHOOTING AT THE CROWD OF 22-THOUSAND PEOPLE.ONCE THEY FIGURED OUT THE NOISE THEY WERE HEARING WERE GUNSHOTS AND NOT FIREWORKS, THEY GOT DOWN AND BEGAN TO RUN.BURGETT REMEMBERS RUNNING AND SEEING A GIRL RUNNING IN FRONT OF THEM AND GETTING HIT, FALLING TO THE GROUND INSTANTLY.SHE SAYS THERE WAS BLOOD EVERYWHERE AND PEOPLE DRAGGING LIFELESS BODIES TO SAFETY.SHE SAYS, “THERE WERE SO MANY PEOPLE TRYING TO HELP OTHERS WHILE IT WAS ALL GOING ON.”BURGETT CONTINUES, ” WE CAME ACROSS A COUPLE GUYS THAT WERE TRYING TO CALM US DOWN, EVEN WHILE THE SHOTS WERE RAINING DOWN.”BURGETT MET CONCERT-GOERS FROM CALIFORNIA WHO TOOK HER AND HER FRIEND TO THEIR HOTEL ROOM FOR SAFETY.SHE SAYS THEY ARE DEVASTATED AND COMPLETELY SHOCKED AND HEARTBROKEN.SHE CALLS IT AN, “ABSOLUTLEY TERRIFYING EXPERIENCE THAT WE WILL NEVER FORGET.”AT LEAST 59 PEOPLE WERE KILLED AND OVER 500 WERE INJURED IN WHAT IS NOW THE DEADLIEST MASS SHOOTING IN AMERICAN HISTORY.
With most A-League squads boasting their full quota of foreigners, finding Australian talent will be the priority for many clubs in January.Already this month, Kwame Yeboah has returned from Germany to sign for Western Sydney Wanderers, while Melbourne Victory have offered NPL star Elvis Kambosa a deserved deal.So who else is out there and where could they end up? Editors’ Picks ‘There is no creativity’ – Can Solskjaer get Man Utd scoring freely again? ‘Everyone legged it on to the pitch!’ – How Foden went from Man City superfan to future superstar Emery out of jail – for now – as brilliant Pepe papers over Arsenal’s cracks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Here are seven Aussies that could or should be on your club’s radar…
The Premier League title race resumes this week, with Liverpool seeking to maintain their place at the top of the table.Leicester City are the visitors to Anfield, with Claude Puel’s Foxes looking to bloody the nose of another one of the big boys.They have already beaten both Manchester City and Chelsea in recent weeks, but will have their work cut out as they seek to become the first visiting side to win at Anfield in the league since April 2017. Article continues below Editors’ Picks ‘There is no creativity’ – Can Solskjaer get Man Utd scoring freely again? ‘Everyone legged it on to the pitch!’ – How Foden went from Man City superfan to future superstar Emery out of jail – for now – as brilliant Pepe papers over Arsenal’s cracks What is Manchester United’s ownership situation and how would Kevin Glazer’s sale of shares affect the club? Liverpool beat Crystal Palace in a nervy encounter 10 days ago, and have won 20 of their 23 league fixtures so far this season. A 21st victory would be the perfect way to end a challenging January for Jurgen Klopp’s men.Here, Goal takes a look at everything you need to know ahead of Wednesday night’s game…Liverpool Injuries Liverpool will make checks on a number of players ahead of the game.Fabinho limped out of the Palace game with a hamstring issue, but returned to light training last week and could be fit to feature despite a bout of illness. Trent Alexander-Arnold (knee) is likely to miss out, but Gini Wijnaldum could be ready to return after missing out against Palace. Virgil van Dijk, who missed training through illness on Friday, should be fine to play.Dejan Lovren will also be available after a hamstring problem.Joe Gomez, Rhian Brewster and Alex Oxlade-Chamberlain are all sidelined.Liverpool Suspensions Liverpool will be without James Milner, who will serve a one-match ban following his dismissal against Crystal Palace.Liverpool Likely Line-UpThe big question for Liverpool surrounds who will play at right back, with Alexander-Arnold set to miss out, Milner suspended and Nathaniel Clyne having been loaned to Bournemouth.Fabinho, if fit, could fill in having performed well there in the past for both Monaco and Brazil. Youngster Rafa Camacho, who made his Premier League debut as a late substitute against Palace, is another, less pedigreed option, while teenage Dutchman Ki-Jana Hoever could be considered.In midfield, Wijnaldum’s return should see him partner Jordan Henderson, with the final place between Xherdan Shaqiri and Naby Keita. Keita was preferred last time out but is yet to make his mark since his move from RB Leipzig.Leicester team news Leicester will check on the fitness of defender Harry Maguire, who suffered an injury in the Foxes’ last game against Wolves.Daniel Amartey is on the long-term absentee list.TV Channel & Kick-Off Time The fixture will be broadcast live in the UK on BT Sport 1, kick-off 8pm. Highlights can be found on Match of the Day, BBC One at 10.45pm.In the United States, the game can be watched live on television on NBC Sports, kick-off 3pm ET. Best Opta Match Facts Liverpool have won their last three league games against Leicester – they last won four in a row against them between February 1987 and September 1996. Leicester have lost six of their last seven away Premier League games against Liverpool (D1), with their last win at Anfield coming in May 2000 (2-0). Liverpool haven’t lost any of their last 19 home midweek games in the Premier League (Tuesday, Wednesday, Thursday), winning 13 and drawing six since a 0-1 loss vs Fulham in May 2012. Liverpool are unbeaten in their last 32 home Premier League games (W23 D9), the longest such run in the division since Man City went 37 without defeat between December 2010 and December 2012. Liverpool are looking to win eight consecutive Premier League home games for the first time since March 2010. The Reds conceded as many goals in their last home league game against Crystal Palace as they had in their previous 15 at Anfield combined (3). Leicester have lost each of their last 11 Premier League games against sides starting the day top of the table, conceding at least twice every time (27 in total) and netting just five in return. Their last such win came on January 31st 1998 at Manchester United. This will be Liverpool’s 10th Premier League game as the side starting top this season, more than they’ve played in any other season in the competition (9 in 1996-97). Leicester have lost their last two Premier League games – the eighth time they’ve lost consecutive league matches under Claude Puel. However, they’ve not lost three in a row in the competition since February 2017 under Claudio Ranieri (a run of five). Only Andrew Cole (11) and Thierry Henry (8) have scored more Premier League goals against Liverpool than Leicester’s Jamie Vardy (7). Liverpool’s Roberto Firmino has committed more fouls without receiving a single yellow or red card than any other Premier League player this season (30). Subscribe to Goal’s Liverpool Correspondent Neil Jones’ weekly email bringing you the best Liverpool FC writing from around the web
STILLWATER, OK – NOVEMBER 7 : A general view of the stadium during the game against the TCU Horned Frogs November 7, 2015 at Boone Pickens Stadium in Stillwater, Oklahoma. The Cowboys defeated the Horned Frogs 49-29. (Photo by Brett Deering/Getty Images)Texas football appears to have taken a big step forward in recent weeks. A trip to Oklahoma State is never easy though.The Pokes are having a down season overall at 4-3, after three straight 10-win years. They’ve jumped on the Longhorns early tonight though.Midway through the second quarter, Oklahoma State leads Texas 24-14 in Stillwater.Quarterback Taylor Cornelius is off to a strong start for Mike Gundy’s team.He’s 12-for-16 for 180 yards and two touchdowns thus far. Oklahoma State has also been extremely productive on the ground, with 129 total rushing yards.Justice Hill and Chuba Hubbard have over 60 yards each thus far.It’s an appropriate fast start, considering who is in Stillwater for the game. Oklahoma State is honoring program legend Barry Sanders, and wearing some amazing throwbacks for the occasion.The ? and the ?????!Welcome back @BarrySanders and the #WarPigs! #okstate pic.twitter.com/IFlIOywYTl— Cowboy Football (@CowboyFB) October 28, 2018Texas did just cut things down to a 10-point lead on a Sam Ehlinger touchdown run from the one-yard line. Still, this is definitely the start you want if you’re an Oklahoma State fan.
A Peek Inside the Joseph Abboud Factory: Italian Fabric, Made in America Over the past several years, Marc Daniels and Ricky Hendry of the cult brand Isaora (pronounced “ee-sah-or-rah”) have been pioneering a brilliant new look to performance sportswear as well as designer menswear. Residents at the prestigious Council of Fashion Designers of America Fashion Incubator on 7th Avenue in New York City this year, the duo is now poised to take modern active wear to the mainstream. On the heels of a new collaboration with Quiksilver and a brand new website, we recently caught up with Daniels to learn more about the brand, from the origins of its name to conquering high fashion.M: Where did the inspiration for the brand come from?MD: Isaora was born from an appreciation of advanced technical apparel and a frustration that we couldn’t find anything that suited our lifestyle or aesthetic in that category.M: And the name?MD: The name is derived from a Spanish phrase that’s popular in South America (where I spent a fair amount of time in my youth) “Ahora Si.” It loosely translates as “Now Yes,” but is used as a rallying cry to the effect of “now’s the time, let’s go!”M: How do you define the Isaora man?MD: The Isaora man combines an active urban lifestyle, a love of good design in all its forms, an understanding and appreciation of quality, and a taste for adventure.M: What is Isaora best known for?MD: Progressive style and premium performance. For example, our Minimal Bomber from Fall 13, a seemingly simple bomber jacket re-imagined in a bonded knit fabric with a waterproof treatment and a laser cut and welded construction. It’s the combination of a very relevant fashion staple with absolutely cutting-edge materials and manufacturing.M: You had your first fashion week presentation in September. How was that for you and are you going to do another?MD: It was exhausting. We were still blacking out the space at 6 am because we decided to do a light show in a space with huge windows in the middle of the day! It was also an important opportunity to show what Isaora is about in the context of our choice. The reaction was really positive. We’ll do it again for sure, but we don’t feel obliged to participate in the circus that is fashion week every season.M: Isaora’s not exactly cheap. How do you justify the prices of the collection?MD: We absolutely don’t want to be cheap, but once people understand what goes into the product they quickly realize we do offer exceptional value. We only use premium materials and work with some of the best factories in the world. Quality is of fundamental importance to us and is something we refuse to compromise on. That comes at a cost, but it’s all relativeM: You’ve had several collaborations. How important are they to the brand?MD: The right collaborations are those which allow us to introduce Isaora to a new audience and make sense from a brand perspective. We’re not going to sell out; if we don’t believe in the project it’s a non-starter. It’s got to be fun and mutually beneficial on some level. That’s pretty much the criteria.M: Ultimately what makes Isaora different from a Nau or an Aether or Icebreaker? MD: Err…no disrespect to those brands, they’re good at what they do. I’d say we’re definitely more progressive and dialed in on the fashion side of things.M: There’s definitely an active influence in fashion. Do you see this being more than just a passing trend, particularly at the high fashion level?MD: Good question…hard to say. I do believe that we’ve been making clothes the same way since basically the invention of the sewing machine! And it’s a natural progression that the materials and manufacturing of clothing will eventually evolve and move forward. In that respect technical and performance attributes are only going to become more prevalent.M: We’re digging the new website. What do you want it to convey? MD: Everything we stand for and represent!M: Tell me about your newest ambassadors and just how do you get to become an Isaora ambassador?MD: They are people we respect who we feel represent the brand. They are our friends and peers who live the lifestyle that defines Isaora. We’d love to hear from anyone who fits that description!M: Finally, what can we expect from Isaora in the spring and the must-have pieces for Spring 2014?MD: For Spring 14 we were interested in street/sport archetypes and designed the collection around certain enduring iconic pieces—the bomber jacket, the sweatpants, the jean jacket, for example. We set about re-imagining these pieces through the Isaora filter, incorporating advanced materials and construction throughout the line. Editors’ Recommendations 1. Isaora 2. Isaora 3. Isaora x Meyerhoffer 4. Isaora 5. Isaora x Quiksilver 6. Isaora 7. Isaora 8. Isaora Why Every Man Should Care About Slow Fashion On the Road with Mikah Meyer, the First Person to Visit Every National Park Site in One Trip Fall in Love with Tentree’s New Fall Collection, Then Plant a Tree The Nomadic Beer Maestros of Evil Twin Brewing Find a Permanent Home in Queens
Plymouth University to Build First Ever Unmanned Ship U.K.’s Plymouth University, autonomous craft specialists MSubs, and yacht designers Shuttleworth Design, have launched pioneering project to design, build and sail the world’s first full-siz… Read more World Maritime News Staff Boxships Collide in Port Klang Two container ships collided while one of the vessels was performing berthing maneuvers in Westport harbor at Port Klang, Malaysia, on August 1, according to local media…. Read more New Suez Canal Up and Running Egypt’s President Abdel Fattah Al-Sisi officially inaugurated the New Suez Canal in the port city of Ismailiya at 2 pm local time today…. Read more Teekay Tankers Buys Entire Suezmax Fleet from Principal Teekay Tankers Ltd. has agreed to acquire a fleet of 12 Suezmax tankers currently owned by Principal Maritime Tankers for an aggregate purchase price of USD 662 million…. Read more Video: MSC Zoe Arrives in Hamburg Mediterranean Shipping Company (MSC) christened its third ‘Oscar Class,’ 19,224 TEU container ship – MSC Zoe – at the Port of Hamburg on August 1…. Read more
WINNIPEG – First Nations leaders in Manitoba want a greater say in the national inquiry into missing and murdered Indigenous women and girls.Sheila North Wilson, grand chief of Manitoba Keewatinowi Okimakanak, which represents First Nations communities across northern Manitoba, says improvements in the way the inquiry communicates with families are badly needed.The MKO and other Indigenous groups are calling for a regional sub-commission for Manitoba that would involve families and survivors.Earlier this week, chief commissioner Marion Buller said government bureaucracy is smothering the inquiry’s ability to do its work on time.She said it was frustrating the inquiry had to follow the same policies and procedures for hiring practices, contracting and technology and budgeting as all government departments.Some Indigenous leader have demanded the commissioners resign and the whole thing be restarted, which Buller has said is not going to happen.But North Wilson said the process just isn’t working.“That would be the tragedy of it — that our families feel so disengaged that they don’t participate,” she said. “This is what we’re trying to avoid. Our leaders and our families and survivors — we frequently talk about whether we want to participate or not. It’s hard to try and stay engaged when you’re not part of the process.”(CTV Winnipeg)
Rabat – Italian giant club AC Milan continues to expand its presence in Africa. The club is set to launch a football academy in the Moroccan southern city of Laayoun.The project forms part of a partnership agreement signed with the city council over a period of three years, AC Milan revealed on Thursday.The football academy will provide football lovers in the region with a technical and educational program based on AC Milan’s training methods. The partnership between the city council and the giant club will give young people in the city the opportunity to benefit from the services of the renowned academy, particularly sessions supervised by the technical manager of the Italian club, Fabio Vicardi, reported Maghreb Arab Press (MAP).The agreement testifies to the efficiency of sports policy carried out in Laayoune. It will also cover the way for the training and development of the youth capacities through allowing them to meet internationally renowned managers and football trainers.AC Milan has a network of more than 100 affiliated clubs in Italy as well as several others in foreign countries.“Each school has the role of Educative Centre that, through football, creates and promotes different sport cultures to all children and adults involved: coaches, directors, and parents,” said the club.The club has been the home of many football stars, including Leonardo Bonucci, Nikola Kalinic, and Lucas Biglia.The club was also a home for Moroccan footballers who were part of the team, including Adel Taarabt. Hachim Mastour, a 19-year old Moroccan footballer, is currently playing for the team.
Rupert Colville, spokesperson for the Office of the High Commissioner for Human Rights (OHCHR), made the announcement during a press conference today in Geneva, where he said the UN had received more detailed information on the incident following an initial investigation carried out by a human rights team on the ground. Earlier this week, the team from the Human Rights and Justice Section of the UN Integrated Peacebuilding Office in CAR (BINUCA) visited the Hopital Communautaire and the Hopital General, the two medical centres where most of the survivors were being treated. The team also visited the site where the shooting took place at a neighbourhood known as PK 12, in the north of Bangui. PK 12, as well two other neighbourhoods, PK 5 and PK 13, was earlier identified by OHCHR as the site of sporadic inter-communal clashes, as reprisal attacks between mostly Muslim ex-Séléka and Christian anti-Balaka militias have escalated steadily over the past three months. The clashes have marked the increasingly sectarian nature of the crisis, which erupted in December 2012 when Séléka rebels launched attacks against the CAR Government. Thousands of people are believed to have been killed thus far, and some 2.2 million, about half the country’s population are now in need of some form of humanitarian aid. As for the 29 March incident, Mr. Colville said that according to the information collected so far, Chadian national army soldiers in a convoy consisting of several military pick-ups entered Bangui, and went to PK 12. “Several sources told the investigating team that they believed the Chadian force had entered Bangui to extract remaining Chadians and other Muslim inhabitants, in order to save them from further attacks by anti-Balaka,” he said. As soon as the convoy reached the market area in PK 12, around 3 p.m., it reportedly opened fire on the population without any provocation, continued Mr. Colville. At the time, the market was crowded, including with many girls and women buying and selling produce. “As panic-stricken people fled in all directions, the soldiers allegedly continued firing indiscriminately.” According to information the human rights team has gathered so far, it seems the Chadian force’s action was totally disproportionate as they were shooting in a crowded market full of unarmed civilians. He said the team’s preliminary findings revealed that some 30 people were killed as a result of the shooting and over 300 were seriously injured, including children, people with disabilities, pregnant women and elderly people, “as they were less able to run for their lives.” Responding to questions about the identity of the soldiers, Mr. Colville said they were not Chadian troops participating in the African-led International Support Mission in CAR (MISCA), but regular Chadian army forces. “It seems they have gone straight back to Chad without being apprehended,” he said, cautioning that it is “a bit early” to ascribe motivation. He said the Commission of Inquiry on the ground in Bangui would obviously look into this incident, as well as others. Mr. Colville said that UN Secretary-General Ban Ki-moon has made very clear that there is a desperate need for a good-sized peacekeeping force, and has requested 10,000 troops. “There is nowhere near that number at the moment, although some European Union troops are due to arrive soon,” he said. Asked about reports that Chad will withdraw from MISCA, Alessandra Vellucci, Chief, Press and External Relations of the UN Information Service in Geneva (UNIS), said the force was an AU-led force and so any questions on that would need to go to the AU. As such, the Organization would not comment on their departure, but there were preparations for a UN presence, which depended on decisions by the Security Council.
Now new research suggests acupuncture could cut the number of hot flushes women experience by half.In a study published in the journal Menopause, more than 200 women who had on average at least four hot flashes or night sweats a day were divided into two groups.One group received 20 acupuncture treatments over a period of six months, while the other group received no acupuncture or any other alternative remedies.Of the 170 women who received acupuncture, nearly half (47 per cent) reported a 47 per cent in frequency of hot flushes, within eight weeks.And one in eight (12 per cent) reported an 85 per cent drop in the number they experienced. One in 25 (four per cent) claimed the ancient Chinese treatment cured them of the feverish flushes completely.Author Dr Nancy Avis, of the Wake Forest Baptist Medical Centre in the US, said acupuncture could be a good solution for many women.Dr Avis said: “Women bothered by hot flushes and night sweats may want to give acupuncture a try as a relatively low-cost, low-risk treatment.”She added: “Women will know pretty quickly if acupuncture will work for them. Women who had a reduction in their hot flushes saw a benefit beginning after about three to four weeks of weekly treatments.” However, acupuncture may not be the answer for everyone. More than a third (37 per cent) of participants saw their hot flushes cut by under 10 per cent.Dr Avis added: “We had hoped to identify some of the characteristics of the women who benefited from acupuncture, but like so many treatments, we could not really tell ahead of time who would benefit.”Dr Mike Cummings, medical director of the British Medical Acupuncture Society, said the research might persuade sceptical women to reconsider the alternative medicine.He said: “This study is one of the first of its kind. In this, we have got some valid data for hot flushes and acupuncture.” Women could halve the number of hot flushes they endure by turning to acupuncture, suggests new research.Hot flushes, a sudden feeling of feverish heat, are the bane of women going through the menopause.While many hot flushes last for just five minutes, as intense heat rises through the body, some women can experience up to 20 a day.And as the menopause lasts for an average of four years, many resort to Hormone Replacement Therapy, or HRT, to rid themselves of hot flushes. Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. Women who had a reduction in their hot flushes saw a benefit beginning after about three to four weeks of weekly treatmentsDr Nancy Avis
Apple took to the stage earlier today to announce the iPhone 5, and there will be plenty of people around the world ready to get their hands on a new smartphone on September 21. Only, many of them will be just as happy to get their hands on the now cheaper iPhone 4S. With the price drop, it may not be entirely obvious which device is the best bang for your buck. Obviously those who want the latest and greatest are happy to spend the extra money, but when you compare the two devices side by side, how do they compare?DimensionsThe iPhone line of devices has an iconic style and design all its own. The iPhone 4S is the second in a refreshed design line, which took the 3.5″ smartphone to a box like shape with glass on both sides. The .37″ thickness feels great in the palm of any hand, while only managing to be 2.31″ wide. The iPhone 5’s .3″ thick frame is noticeably thinner despite being more powerful and containing more hardware. The difference in width is negligible, so they are going to feel quite similar in the hand.DisplaySince the original iPhone, this line of smartphone has had the same screen size. When the iPhone 4 was announced, we saw a significant increase in screen quality with the Retina display, but still the same size screen. The iPhone 4S has a 3.5″ IPS display that can produce a 960 x 640 resolution image. At 330 ppi, this 4:3 display is still one of the best displays available when compared to other devices. The iPhone 5’s new larger screen breaks the iPhone mold a bit, but also ads quite a bit, too. The 4″ screen offers up a 1136 x 640 resolution display. On top of being a larger screen, the aspect ratio on this 326 ppi screen has also changed to 16:9. It has much better color saturation, and touch is integrated directly into the display making it more accurate.WirelessApple has lagged behind the rest of the smartphone world a bit when it comes to the next generation of wireless connectivity. The iPhone 4S is a 3G device, capable of connecting to HSPA+ on AT&T and CDMA on Sprint and Verizon networks. While these networks are more than capable of delivering normal content, nearly every carrier is fast at work pushing the new LTE network across the world. On top of the 3G radio in the 4S, the iPhone 5’s LTE radio will be capable of taking advantage of the significant increase in speeds offered by many global carriers.ProcessorEvery version of the iPhone has had a special processor that has been made under Apple’s supervision by other companies. The iPhone 4S features a dual-core A5 processor clocked to 800MHz. While many have seen this processor as being underclocked, the iPhone 4S is almost never found to be sluggish or lagging. The processor in the iPhone 5 is Apple’s new A6 chip, which boasts an increase in performance as well a smaller overall processor. Apple says both the CPU and GPU offers a 2x performance bump over the A5 chip, so iOS should fly along.RAMIn a world where you can’t find an Android device out there with less than 1GB of RAM, the 512mb of RAM in the iPhone 4S may seem insufficient. When you hold a 4S in your hand and use it, however, you find that 512mb is more than enough to drive this smartphone. Given the new processor in the iPhone 5, however, it only makes sense that Apple’s latest smartphone would be packing 1GB of RAM to keep up with the much faster processor. 1GB isn’t officially listed on Apple’s iPhone 5 spec sheet, but we’d be very surprised if this wasn’t the amount being used.CameraThe iPhone 4S camera is the standard to which most other smartphone cameras are compared to. The 8MP camera on the iPhone 4S is capable of taking terrific photos, as well as recording 1080p videos. The software that accompanies the iPhone camera allows users to take photos that are often mistaken for professional shots. The iPhone 5 camera is still 8MP (3264 x 2448), but the technology inside is significantly improved. The backlit sensor and five element lens on the iPhone 5 camera, being called iSight, will allow photos to be taken in low light situations with better noise reduction. There’s also a Panorama view capable of capturing 28MP images.BatteryThere’s no way to access the battery on an iPhone, so it is important that the device be able to get you through the whole day. The iPhone 4S has been able to deliver an all day experience to many users with its 1,432mAh battery, which according to Apple gets you about six hours of continuous heavy use. Apple’s latest iPhone is reportedly packing a 1440mAh battery, which promises to deliver eight hours of continuous heavy use. Especially given the LTE radio inside the iPhone 5, that is an impressive figure.StorageThere’s no removable storage offered with the iPhone line, so whatever model you get for storage you are stuck with, unless you get something like a WiDrive. The iPhone 4S is available in 16GB, 32GB, and 64GB, with a price scale to match. The iPhone 5 mirrors this exactly on both storage levels and price ($199, $299, and $399 respectively).WeightYour phone is something that you have in your pocket all day, every day. While it seems silly to pay attention to something like weight when it comes to something so small, the difference half an ounce makes is surprising. The iPhone 4S weighs in at 4.9oz, which is lighter than many of the other phones that are out there today. Compared to the iPhone 5, which weighs in at 3.95 oz, the handset will probably only feel lighter if you happen to be holding both of them.And there you have it. Apple has released an obviously superior product with the iPhone 5, but if you are not interested in the very top of the line, the less expensive iPhone 4S is still a great phone by today’s standards. Which one will you choose?