Andrew Wiggins signs contract extension with Timberwolves Jo Koy: My brain always wants to think funny Don’t miss out on the latest news and information. Kiss-and-tell matinee idol’s conquests: True stories or tall tales? Margot Robbie talks about filming ‘Bombshell’s’ disturbing sexual harassment scene MOST READ “You don’t have wholesale changes based on the ball being 2 inches wide or 2 inches in,” he said. “We will look at everything, obviously, and all of our programs, both the national team and all the development stuff. But we’ve got a lot of pieces in place that we think are very good and have been coming along.”The U.S. returned to the World Cup in 1990 after a 40-year absence, and soccer grew at an exponential rate, helped by the U.S. hosting the tournament in 1994. Major League Soccer launched two years later; cable television and the Internet brought top European clubs to American televisions and later laptops and cell phones.European clubs discovered there was huge money to be made by playing preseason exhibitions across the pond, growing the sport’s audience.American sponsors started treating soccer like a major sport, if not at the level of the NFL, baseball and the NBA, at least as prominent as the NHL, golf and tennis.Still, the national team peaked with its quarterfinal appearance at the 2002 World Cup. The U.S. failed to qualify for the 2012 and 2016 men’s Olympic soccer tournaments, a generational talent gap evident when a creaky defense repeatedly broke down during qualifying. There were no young goalkeepers considered challengers to Howard and Brad Guzan.“This has been coming for a while. I think it’s just kind of been building up,” former U.S. defender Marcelo Balboa said Wednesday.Elected head of the USSF in 2006 after a quarter-century helping build the national team and federation, Gulati has not said whether he will seek a fourth and final four-year term in February.More immediately, a decision must be made on whether the national team plays exhibitions during the November fixture dates and who will coach. Bruce Arena, brought back when Jurgen Klinsmann was fired last November after a 0-2 start in the hexagonal, figures to depart later this year or next.Among the possible American candidates are Tab Ramos, coach of the U.S. under-20 team since 2011; Peter Vermes, coach of Sporting Kansas City since 2009; and Huddersfield manager David Wagner. Atlanta United’s Tata Martino, a former coach of Argentina and Barcelona, is among the foreigners who could be considered. An interim coach is a possibility.Surprisingly, Arena said no major shifts need to be made in the federation’s operations. LATEST STORIES View comments Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Coco’s house rules on ‘Probinsyano’ set Jake says relationship with Shaina ‘goes beyond physical attraction’ Steam emission over Taal’s main crater ‘steady’ for past 24 hours “There’s nothing wrong with what we’re doing,” he maintained. “Certainly I think as our league continues to grow, it benefits the national team program. We have some good young players coming up. Nothing has to change. To make any kind of crazy changes I think would be foolish. We’re building a good system in our professional league. We have players playing abroad of some quality. There’s enough there.”Sports Related Videospowered by AdSparcRead Next “In the almost 12 years during which Sunil Gulati has been the USSF’s president, little or nothing has been done to enhance our prospects,” Commisso said in a statement. “The leadership of U.S. Soccer has failed all of its stakeholders: players, fans, sponsors and those of us who have invested in professional soccer. Getting back on track requires fundamental change in the structure and management of the sport in our country, starting with a change in the federation’s leadership.”While fans fulminated over the front office, the next national team coach must instigate a ruthless roster purge. The Tim Howard/Clint Dempsey/Michael Bradley era is over, and pretty much any player older than 26 will be past his past his prime when the World Cup in Qatar kicks off in November 2022. The Americans won’t even play a competitive match for nearly two years, until the 2019 CONCACAF Gold Cup.By then, Christian Pulisic, at 19 already the top American, should be surrounded with other players on the rise, such as 19-year-old midfielder Weston Mckennie, who has started Schalke’s last three games in the German Bundesliga. Haji Wright, a 19-year-old winger loaned from Schalke to second-division Sandhausen, is another top prospect along with forward Josh Sargent, who agreed last month to sign with Werder Bremen on his 18th birthday in FebruaryMatt Miazga and Cameron Carter-Vickers should be tested in defense as the team reorients to 2022.A shocked Gulati was measured in his reaction.ADVERTISEMENT “Unacceptable,” tweeted former Health and Human Services Secretary Donna Shalala, a U.S. Soccer Federation board member. “For us in USSoccer more than a wake-up call. Time for revolution. Need long term plan that is smart.”After American soccer’s Waterloo, the fallout almost surely will lead to a new coach and possibly a new USSF head. There also figure to be calls for a reexamination of the player development structure, from youth teams through academies designed with the hope of producing elite prospects.FEATURED STORIESSPORTSRedemption is sweet for Ginebra, Scottie ThompsonSPORTSMayweather beats Pacquiao, Canelo for ‘Fighter of the Decade’SPORTSFederer blasts lack of communication on Australian Open smog“There is no denying that this is a setback for all of us involved with the game in our country,” Major League Soccer said in a statement.New York Cosmos owner Rocco Commisso, chairman of the lower-level North American Soccer League that has sued the USSF, called for federation President Sunil Gulati to resign along with board members and senior administrators he put in place. OSG plea to revoke ABS-CBN franchise ‘a duplicitous move’ – Lacson It’s too early to present Duterte’s ‘legacy’ – Lacson This file photo taken on April 10, 2017 shows Sunil Gulati, President of United States Soccer Federation, speaking at a press conference in New York./ AFP PHOTO / KENA BETANCURCOUVA, Trinidad—When soccer holds its world’s fair in Russia next June, the American pavilion will be glaringly absent.A bumbling, stumbling, tumbling World Cup qualifying campaign ended Tuesday night with a calamitous 2-1 loss to already eliminated Trinidad and Tobago, the 99th-ranked nation in the world, when merely a tie was necessary to eke out the final automatic World Cup berth from one of soccer’s weakest regions.ADVERTISEMENT Jake says relationship with Shaina ‘goes beyond physical attraction’
Jim McLaughlin, Chairman of the Donegal Family Resource Centre, in Donegal Town has condemned the Government for implementing measures which he claims “attacks ordinary workers”.Mr McLaughlin told Donegal Daily: “The Government have used this budget to introduce measures which will effect workers who must go on sick leave.“This means that a worker certified as being unfit to work by their GP will not be entitled to receive sickness benefit for the first six days. “This will particularly impact on the vast majority of private sector workers who do not have sick pay schemes in the work place, forcing hard pressed working people to go without.”Mr McLaughlin said the cut was particularly cruel for workers who were helping to keep the country afloat.“These very workers are contributing to the benefits system yet are increasingly being denied any support from it,” he said.“The reality is that private sector workers are being constantly drained of their income to support a completely unfair system”. BUDGET REACTION: SICK PAY CUT IS ATTACK ON ORDINARY PEOPLE, SAYS RESOURCE CENTRE BOSS was last modified: October 16th, 2013 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:budgetDonegal Town resource centreJim McLaughlinsick pay cuts
In one of my recent posts I spoke about company cultures and my opinions of three examples.A performance based culture wins all of the time!!The keys to creating a performance based culture are:Clearly communicate your company goals, aspirations and values, and make them stick with every employee.Every employee should have clearly measurable goals and at least one goal that reflects the performance of the company as a whole.Make sure that each organizational team or function has accountability to each other and are measured to the success of this accountability.Most executive management teams want to have this culture but internal teams tend to silo into their own sub cultures. Great companies are consistent throughout.AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to PrintPrintShare to EmailEmailShare to MoreAddThis
Source:http://www.media.uzh.ch/en/Press-Releases/2018/Melanoma.html Jul 2 2018Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell’s external environment. Researchers at the University of Zurich have now shown that these fine sensory antennae play a key role in the formation of melanoma. When cilia are prevented from developing in benign pigment cells, the cells degenerate and develop an aggressive form of melanoma.Melanomas are one of the most aggressive types of tumors in humans. Despite remarkable success with new forms of treatment such as immunotherapies, there are still many melanoma patients who cannot be cured or who later suffer a recurrence of the disease following successful treatment. An in-depth understanding of the tumor’s biology is thus essential for developing novel therapeutic approaches. The main question is which changes in a benign cell cause it to progress into a malignant tumor.Related StoriesNew clinical genomic testing helps identify mutations that drive childhood melanomaPhysicians trained in dermatoscopy can improve odds for early detection of melanomaResearchers find possible counterpunch to drug resistance of melanomaFormation and spread of melanoma also regulated epigeneticallyA team of researchers led by Lukas Sommer, professor at the Institute of Anatomy at the University of Zurich (UZH), has now been able to show that in addition to genetic causes such as mutations in the DNA, epigenetic factors also play a role in the formation and spread of melanoma. While epigenetic factors don’t directly influence the gene sequence, they do regulate how efficiently certain genes are transcribed in the cells. The UZH researchers focused on the EZH2 protein, which – unlike in benign cells – is very common in melanoma cells and plays a central role in melanoma formation.EZH2 suppresses ciliary genes and leads to metastasisTo find out how epigenetic factors contribute to the melanoma’s aggressive behavior, the scientists examined all the genes that are regulated by EZH2. “We were very surprised to find many genes that are jointly responsible for the formation of cilia,” says study leader Sommer. It seems that cilia genes are suppressed by EZH2, which means that malignant melanoma cells have much fewer of these fine sensory hairs than the skin’s benign pigment cells. With the help of human melanoma cells and mouse models, the researchers succeeded in demonstrating that loss of cilia in pigment cells activates carcinogenic signaling pathways, ultimately resulting in the formation of aggressive, metastatic melanoma.Approach for novel tumor therapiesThere are many types of cancers composed of cells that have lost their cilia. “The epigenetic regulation of cilia formation that we’ve now discovered in melanoma is, therefore, likely also relevant for the formation of other types of cancers, such as breast or brain tumors,” remarks Lukas Sommer. Drugs that block EZH2 probably offer a promising strategy when it comes to treating melanoma, possibly in combination with immunotherapies, according to Sommer.